The Mayo Campus is located next to Mayo General Hospital, less than ten minutes walk from Castlebar Town.

It opened its doors to students in 1994, in the west wing of the Hospital.  The entire building has been sensitively restored to retain as much as possible of the original architecture, while providing the modern facilities and services required for students and staff.  

The Mayo Campus specialises in nursing and outdoor education, as well as offering courses in business, technology, health sciences and more.  

In 2011, it became the first Institute of Technology campus in Ireland to be awarded Green Campus status.