Drug Design (PHCM081) German University in Cairo (GUC)

The course allows the student to get introduced to non-computational and computational methods in drug design, pharmacophores, the relevance of and methods involved in the improvement of binding interactions between drug and its targets (finding lead compounds, the role of combinatorial chemistry, drug actions at receptors, improvement of pharmacokinetic properties of drugs. Computer-aided drug design and molecular modeling. Relevance of drug metabolism regarding the affinity of molecules to pharmacological receptors, transporters and metabolizing enzymes in sequential pathways including examples for active metabolites and prodrugs.In the computer course the students will get acquainted with methods used to correlate physicochemical properties with biological activity and the basics of computer-based methods of 3D-QSAR in order to understand their relevance for lead identification, modification and optimization. Practical lab course deals with qualitative and quantitative analysis of drug substances, degradation products and metabolites in complex mixtures (like drug formulations, biological fluids), the identification and quantification of molecules in toxicological material as well as biological fluids in therapeutic drug monitoring.

The German University in Cairo, GUC, is an Egyptian Private University founded by the presidential decree 27/2002, according to the law number 101/1992 and its executive regulations number 355/1996.

German university in Cairo/Deutsche Universität in Kairo has been established in 2002 in cooperation with the State Universities of Ulm and Stuttgart, under the patronage of the Egyptian Ministry of Higher Education, the Ministry of Science, Research and Arts, State of Baden- Württemberg, Germany, and supported by the German Academic Exchange Service (DAAD), the German Embassy in Cairo, the Arab/German Chamber of Industry and Commerce (AHK), the Federal Ministry of Education and Research, Germany, The State University of Tübingen and The State University of Mannheim.

The German University in Cairo is an independent, non-profit oriented Egyptian private institution, managed by a consortium of Germans and Egyptians with the vision of building a leading center of excellence in teaching and research that will effectively contribute to the general welfare nationally and internationally and endeavour the scientific, technical, economic and cultural cooperation between Egypt and Germany.

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